منابع مشابه
A TAD closer to ATM
Ataxia telangiectasia mutated (ATM) has been known for decades as the main kinase mediating the DNA double-strand break response. Our recent findings suggest that its major role at the sites of breaks likely resides in its ability to modify both the local chromatin landscape and the global chromosome organization in order to promote repair accuracy.
متن کاملAdam Steensberg Tad
Please cite this article in press as: Steensberg, A. Beyond biomarkers in drug discovery and d 1359-6446/ 2014 Elsevier Ltd. All rights reserved. http://dx.doi.org/10.1016/j.drudis.2014.12.009 market; this is no longer a certainty. Today, most new drugs compete against numerous therapies, including nonpharmaceutical options. To create new value these therapies need to provide benefits beyond ex...
متن کاملTAD disruption as oncogenic driver.
Topologically Associating Domains (TADs) are conserved during evolution and play roles in guiding and constraining long-range regulation of gene expression. Disruption of TAD boundaries results in aberrant gene expression by exposing genes to inappropriate regulatory elements. Recent studies have shown that TAD disruption is often found in cancer cells and contributes to oncogenesis through two...
متن کاملA TAD better for myeloma therapy?
In this issue of Blood, Lokhorst and colleagues report on the results of HOVON-50, a phase 3 randomized trial designed to evaluate the effects of thalidomide during induction treatment and as maintenance in patients with multiple myeloma. There were 556 patients randomly assigned either to 3 cycles of VAD or to TAD. All patients were to receive high-dose melphalan with autologous stem cell supp...
متن کاملNotes on amalgamated duplication of a ring along an ideal
In this paper, we study some ring theoretic properties of the amalgamated duplication ring $Rbowtie I$ of a commutative Noetherian ring $R$ along an ideal $I$ of $R$ which was introduced by D'Anna and Fontana. Indeed, it is determined that when $Rbowtie I$ satisfies Serre's conditions $(R_n)$ and $(S_n)$, and when is a normal ring, a generalized Cohen-Macaulay ring and finally a filter ring.
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ژورنال
عنوان ژورنال: Nature Reviews Molecular Cell Biology
سال: 2016
ISSN: 1471-0072,1471-0080
DOI: 10.1038/nrm.2016.144